by Admin | Apr 11, 2025 | Hereditary
Every year on 11 April, World Parkinson’s Day raises awareness about this chronic and progressive neurodegenerative disorder that affects millions of people worldwide. This day serves to highlight the importance of early diagnosis, continued scientific research, and the need for comprehensive care strategies that support both patients and caregivers to finally improve the quality of life of those affected.
Parkinson’s disease (PD) is currently one of the fastest-growing neurological disorders in the world. In Europe alone, more than 1.2 million people are living with the condition—a figure that is expected to double by 2030. Globally, the number of people affected is estimated to reach 11.8 million.
PD is a complex and progressive neurodegenerative disorder that affects movement, cognitive function, and overall quality of life. Its symptoms and progression vary widely, making each case unique. Although its exact cause remains unknown, current research points to a combination of genetic and environmental factors.
Despite notable advances in treatment, there is still no cure. Existing therapies focus primarily on managing symptoms rather than slowing the disease’s progression, highlighting the urgency of continued research and innovation in both medical and supportive care strategies.
HEREDITARY’S contribution
The need for early detection and personalised treatment has never been greater — and this is where the HEREDITARY project steps in.
Funded by the European Union’s Horizon Europe programme, HEREDITARY is unlocking the potential of health data spaces and AI-driven reasoning systems to advance the understanding, detection, and treatment of neurodegenerative diseases like Parkinson’s.
In Use Case 3, HEREDITARY integrates a wide range of multimodal data—including brain imaging, ophthalmic scans, clinical records, and more—to make progress in tackling this disease. The UCD is currently leading an innovative research through advanced AI techniques such as deep learning and unsupervised learning, aiming to identify early biomarkers of Parkinson’s, particularly those visible in the eye, and to uncover patterns that could help predict disease development and progression. This integrative approach not only supports earlier and more accurate diagnosis but also opens new doors to personalized treatment strategies.
HEREDITARY is part of a broader movement across Europe. Other impactful EU-funded projects include:
- The AIPD Project aims to create an international, interdisciplinary graduate school to train the next generation of medical data scientists with a strong translational focus.
- The BICEPS Project is working under the hypothesis that immune system dysfunction plays a role in Parkinson Disease and will utilise advances in systems biology and AI towards new diagnostics and therapies..
- The AI-PROGNOSIS Project aims to advance PD diagnosis and care through novel predictive models combined with digital biomarkers from everyday devices.
- The UNMASK Project is continuing the work of the SCENT project on a bio-based artificial nose system that can be employed for the diagnosis of neurodegenerative diseases such as Parkinson’s and Alzheimer’s diseases.
Parkinson’s affects people of all ages, genders, and backgrounds — and raising awareness is key to driving more research, better care pathways, and early diagnostic innovations that can improve quality of life for millions. As we commemorate World Parkinson’s Day, HEREDITARY stands with researchers, clinicians, patients, and caregivers across Europe to foster a future where technology empowers earlier diagnosis, personalised care, and better lives for those affected by Parkinson’s disease.
by Admin | Feb 26, 2025 | Events
The HEREDITARY consortium will take part in the upcoming JARDIN Hackathon on Health Data Federated Querying, an event organized by the European Commission. The Hackathon aims to tackle key challenges in integrating sensitive health data across multiple institutions while exploring innovative solutions. Its objectives align closely with our project’s goals, particularly in the fields of federated analytics and learning. A key focus will be enabling federated queries, allowing researchers to extract valuable insights without compromising patient privacy or data security.
This initiative brings together experts from diverse fields, fostering collaboration and knowledge exchange to address these complex issues effectively.
Key topics to be explored during the hackathon include:
- Harmonizing data exports from healthcare provider systems.
- Developing tools and methods for federated data querying.
- Enhancing semantic representation and ensuring compliance with FAIR data principles.
The event is open to professionals from various disciplines, including clinicians, data stewards, analysts, developers, and semantic web specialists, all of whom play a crucial role in advancing data harmonization and secure querying practices.
Although an official event date has not yet been set, the registration deadline for the hackathon is March 5, 2025. We invite all interested participants to seize this opportunity to contribute to the future of digital healthcare while gaining valuable insights. Check here the preliminary agenda!
by Admin | Feb 21, 2025 | Events
On February 20, 2025, in Udine, Italy, the HEREDITARY project participated in the Conference on Information and Research science Connecting to Digital and Library science (IRCDL) 2025, presenting the paper titled “Extending Nanopublications with Knowledge Provenance for Multi-Source Scientific Assertions”. A fantastic work submitted by Fabio Giachelle, Stefano Marchesin, Laura Menotti, and Gianmaria Silvello from the University of Padua, that was honored with the Best Paper Award, standing out at this prestigious conference.
This builds on the success of HEREDITARY at IRCDL for the second consecutive year. In 2024, the team introduced “Publishing CoreKB Facts as Nanopublications”, a study on extracting gene expression-cancer associations from scientific literature and storing them in the CoreKB platform for machine-readable and shareable insights.
This year’s award-winning paper extends the nanopublication model by incorporating knowledge provenance. Unlike traditional models that track assertions from single sources, this approach enables multi-source scientific assertions. Applied to data from the CORE system, this method generated 197.511 extended nanopublications, improving the identification, representation, and citation of gene expression-cancer associations.
About IRCDL
The Conference on Information and Research science Connecting to Digital and Library science (IRCDL) is a key annual event for researchers working in digital libraries and related fields. It covers a wide range of topics, from digital content management to theoretical information models. The conference brings together experts from academia, government, industry, and other sectors, drawing on disciplines such as computer science, digital humanities, information science, archival studies, and cultural heritage. The 2025 edition (the 21st of the Conference) featured two tracks: one on Computer Science Foundations for Digital Libraries and another on Digital Humanities.
The recognition of the HEREDITARY research at IRCDL 2025 highlights our significant contributions to scientific knowledge and health data, driving forward the frontiers of personalized health solutions.
by Admin | Nov 18, 2024 | Events, Hereditary
In the framework of Work Package 5: Visual Analytics and Interaction, Graz University of Technology (WP5 leader) presented the poster DROPLETS: A Marker Design for visually enhancing Local Cluster Associations on Sunday 13 October as part of a submission to the Bio+MedVis Challenge at IEEE VIS 2024.
The research of TU Graz, focused on the visualisation of high dimensional data, received an award for the novelty and innovative Visualization technique design. It was presented by Stefan Lengauer in a virtual format, who is one of the authors along with Peter Waldert and Tobias Schreck. The summary poster, the full publication, the video presentation and the source code for generating the Droplets layout are available and can be consulted.
This year’s objective of the Bio+MedVis Challenge was to redesign an existing visualization of multi-cell gene expressions of tissue samples. In this, multiple cells are accumulated into pixels. For each pixel, the visualization should convey the prevalence and extent of cell types it is composed of in a proportional relation. The provided baseline technique of superimposed Pie charts limits the perception of regions with coherent cell-type compositions, which constitutes one of the essential visual analytics tasks.
As a response, TU Graz proposed a novel marker design: DROPLETS, a space-saving design for visually enhancing the presence of clusters and regional borders. This concept was evaluated for the given tissue sample and compared with the given baseline and other alternatives.
About the IEEE VIS 2024
IEEE VIS 2024 was the year’s premier forum for advances in theory, methods, and applications of visualization and visual analytics. The conference convened an international community of researchers and practitioners from universities, government, and industry to exchange recent findings on the design and use of visualization tools.
Join us and TU Graz to learn more about Hereditary Project and how visualization techniques help to face the critical challenge of leveraging multimodal health data.
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